Estradiol (E2) is a type of estrogen and is the main ‘female’ sex hormone. E2 is essential for egg production. Your E2 levels fall as you age, so low levels can be a sign that you’re menopausal. If your E2 levels are imbalanced, it can cause a wide range of symptoms like irregular periods, hot flashes, fatigue, headaches, sleep problems, anxiety, depression, low sex drive, and worse premenstrual syndrome (PMS). If you have low E2 level you have a higher chance of having osteoporosis, stroke, heart attack, dementia and skin aging as you age.